Heck yeah! That's what I'm running, it's not maxed out, but gets really good frames with about everything at Medium (1600x900 resolution). In my opinion, you can't really notice the difference between all high and all medium anyway.
I have a 750ti. It works fine. You won't be getting the absolute most out of the game but it'll keep it from from looking like NFS3 lol. A decent, hopefully Intel, CPU seems to be the most important thing for this game.
I'm feeling a lot better about the 750ti after todays update. All max settings bar SSAO and all the maps run 35-60fps, and thats with an old athlon x4 635 and 4gb ram.