I think I'd take some luxury convertible, like a Bentley Continental or Rolls-Royce Dawn, and drive it through Nevada, on the route Duke and Gonzo took in Fear and Loathing in Las Vegas. The soundtrack would be some 60s and 70s rock - Jefferson Airplane, Creedence Clearwater Revival, The Rolling Stones, Aerosmith, Kansas, etc.
1990 Eagle Talon TSI AWD through the highways on the west coast of the US I would listen to whatever songs I have in my metal playlist on Spotify
For me I'd travel along what remains of Route 66 in a 50's car. Like a Bel-Air or a Ford Custom 300. Listening to music from the 50's and 60's.
I would want to take New York City-Los Angeles road trip, with detour to various places in USA with Dodge Charger R/T from 1969, because you cannot do a road trip across America, without classic American Muscle.